Mesi is a small village of the prefecture of Rethymno located approximately 12 km southeast of the , between the villages of and .
Although mentioned in the Venetian censuses of the 16th century as Mesi, it has been founded since the Byzantine period, as it once was the Byzantine Episcopal see. It is possible, indeed, that the village was called Mesi (=Middle) because of its location, since it is situated between two other dioceses, the Kalamonas and.
Mesi is one of the typical villages with many Venetian buildings, where the houses are built close to each other with beautiful courtyards. In recent years it has become quite deserted compared to the past, but still maintains its traditionalism and the solid character.
The Mesi village is a birthplace of George Hortatsis and at the southeastern part of it there is the Kioumprá cave, where, in a beautifully designed space, a war memorial has been erected in the place of a clash of the resistance fighters with the Germans during the occupation.